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Avoiding Unnecessary Surgeries: New Thyroid Cancer Test

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PALM BEACH, Fla. (Ivanhoe Newswire) - Thyroid cancer is the fastest growing cancer in the United States. Biopsies can catch the problem before it's too late, but many times the results are inconclusive. That means patients might have to have their thyroids removed, even if there is no cancer.

Ferne Berger's life was turned upside down when an ultrasound showed a nodule on her thyroid gland.  Ferne had a biopsy, but her results were inconclusive.

"The fear of them being malignant was certainly very scary," thyroid patient, Ferne Berger, told Ivanhoe.

Half a million nodules are biopsied each year and Dr. Paul Aoun said up to 30 percent of the time results come back inconclusive.

The traditional next step for those patients has been to remove all or part of the thyroid.

"…only 25-percent end up having cancer," Endocrinologist, Paul Aoun, DO, PhD,  at Palm Beach Diabetes & Endocrine Specialists, told Ivanhoe.

Now, if a biopsy comes back inconclusive, doctors have a new tool to test the sample.  The gene expression classifier test measures 142 gene patterns, including those present in thyroid cancer and can reclassify nodules as benign or possibly malignant.

"That could result in saving about half the patients proceeding to unnecessary surgery," Dr. Aoun said.

A study showed the test is 94 percent accurate in reclassifying inconclusive results as benign.  Another study showed the test helped reduce surgery rates by 90 percent.

Ferne's results showed her nodule was benign and she did not need surgery.

"It was a big weight off my shoulders," Ferne explained.

Studies show incorporating the classifier test into the diagnosis process has resulted in higher quality of life for patients and less costs to the healthcare system.

RESEARCH SUMMARY

BACKGROUND:  Thyroid cancer is a disease that happens when abnormal cells begin to grow in the thyroid gland.  The thyroid gland is a buttery shaped glad in the front of the neck that makes hormones to regulate the way the body uses energy and that help the body work normally.  It is the fastest growing cancer in the United States.  While the cause of thyroid cancer is unknown, experts believe that like other types of cancer changes in the DNA of the cells play a role.  People who have been exposed to a lot of radiation have a greater chance of getting thyroid cancer. (Source: webmd.com)

SYMPTOMS:  Several symptoms can result from thyroid cancer:

  • Trouble breathing or constant wheezing
  • Trouble swallowing
  • Hoarse voice
  • Pain in the neck or ears
  • Lumps or swelling in the neck (the most common symptom)

TREATMENT:  If there is a lump in the neck, then a doctor will take a biopsy of the thyroid gland to check for cancer cells.  A biopsy is a simple procedure in which a small piece of the thyroid tissue is removed.  Sometimes the result of the biopsy is not clear and often times results in surgery. (Source: webmd.com)

NEW TECHNOLOGY:  Half a million nodules are biopsied each year and 20 to 30 percent of these are inconclusive.  A ground breaking new test, called the gene expression test, measures inconclusive tissue.  It measures 142 gene patterns that are present in thyroid cancer and can tell if the nodule is benign or malignant.  The test is an ultrasound-guided needle biopsy that can accurately identify 62 to 85 percent of thyroid nodules as benign.  This new breakthrough can help people avoid expensive unnecessary surgeries. (Source: uphs.upenn.edu)

INTERVIEW

Paul Aoun, DO, PhD, Endocrinologist at Palm Beach Diabetes & Endocrine Specialists, talks about a new genomic test to identify if a questionable thyroid nodule biopsy is benign or suspicious for cancer

What are the reasons that people come to check their thyroid?

Dr. Aoun: There are several reasons for which people come to have their thyroid checked. One is having symptoms and/or laboratory tests suggestive of either under or overproduction of thyroid hormones. Another reason is that people notice something in their neck such as a lump that upon further evaluation is determined to be a thyroid nodule, or growth in the thyroid gland.

How common are those nodules?

Dr. Aoun:  Thyroid nodules are very common. In fact, among people over the age of fifty, fifty percent or more will have thyroid nodules. So, it's more common to have thyroid nodules over that age than to not have thyroid nodules.

But what are they looking for, when you're at home and you feel a lump? What is it you're looking for exactly?

Dr. Aoun:  The majority of thyroid nodules are not felt at home. They're usually picked up by the physician during an exam or through something we call an incidental finding. That is when a CT scan or an ultrasound of the neck done for another reason, picks up a thyroid nodule.

So most of the time it's something that they have no idea about?

Dr. Aoun:  Exactly.

How dangerous can it get?

Dr. Aoun:  It's not very dangerous. The majority of nodules are small and benign. If they get too large to the point that they start causing compressive symptoms, such as pushing against the windpipe or the esophagus, then patients might experience changes in their voices or complain of food getting stuck in their throats.

So if it gets picked up by the exam you get a biopsy?

Dr. Aoun:  The next step is to get an ultrasound and thyroid blood tests. If the thyroid function tests are okay and the nodule warrants being biopsied, I will then proceed to fine needle aspiration, or FNA.

So how invasive is this?

Dr. Aoun:  It's not very invasive. We clean the neck, spray some numbing medication, use a thin needle to get a few samples from the nodule and we send the collected cells for analysis.

What are usually the findings?

Dr. Aoun:  There are four possible outcomes. It could come back as benign, which is the most common finding. A second possibility is malignant or suspicious for cancer. A third option is non-diagnostic, which means, the sample is suboptimal and thus a diagnosis cannot be made. In up to twenty to thirty percent of cases at most, we get inconclusive or indeterminate results, which means that the makeup of the nodule is not clear-cut to help make a definitive diagnosis.

So benign is good, it means that you're good to go, no surgery.

Dr. Aoun: Correct, if the result is benign, then there is no need for surgery, and we usually continue to monitor those patients with serial ultrasounds, as needed.  If a benign nodule gets too large and starts causing problems, then surgery is warranted. If the nodule is cancerous, then the recommended next step is surgery. If the FNA result is, non-diagnostic, we usually repeat the biopsy. For nodules with indeterminate findings, the traditional approach had been to send the patient to surgery. This recommendation, however, has been modified after cytogenetic testings, such as the Afirma test, have become available.

So what are you removing when you go in to surgery?

Dr. Aoun:  Surgery has traditionally involved removing all or part of the thyroid.

How often do you perform the FNA, and do you perform it yourself?

Dr. Aoun:  I do. I look at the ultrasound sonographic features of the nodule, take in-to consideration the patient's clinical risk factors, such as radiation exposure or family history of thyroid cancer, and decide accordingly on whether to proceed to FNA.

So how often do you do it here yourself? How many have you done so far?

Dr. Aoun: I've done several. I can't give you an exact number, but I can tell you that about half a million nodules or so get biopsied on a yearly basis in the U.S..

From those half a million how often do they come out inconclusive?

Dr. Aoun: If we consider a twenty percent cut-off, that would be about a hundred thousand indeterminate biopsies per year.

So a hundred thousand people are actually going in to surgery not knowing if they need to or not?

Dr. Aoun: On pathology analysis after surgery, about seventy-five percent of those with indeterminate nodules will end up having a benign disease. Only twenty-five percent or so will turn out to have cancer.

So they're going through this process of surgery. For patients, what is the recovery time, what do they go through, and how does that change their life?

Dr. Aoun: There is a lifelong requirement for thyroid hormone replacement therapy if the whole thyroid is removed. Also, one must factor in the potential risks of surgery.

How invasive is the surgery?

Dr. Aoun: An incision is done in the neck to remove part of or the whole thyroid. Recovery is fairly good. If the patient is stable and there are no complications, they usually go home the next day.

So now we have this test that's called the Afirma Gene Expression Classifier?

Dr. Aoun:  That is correct.

Can you explain what it does?

Dr. Aoun:  The Afirma gene expression classifier comes in-to play when a patient has an indeterminate thyroid nodule FNA. Traditionally, those patients were sent to surgery. Now the Afirma gene expression classifier helps sort out whether the nodule appears benign or not. If benign, the patient can avoid surgery and be monitored instead. If, however, the results of the genetic test are suspicious for cancer, we recommend that those patients still proceed to surgery.

How does it work exactly, how does it know?

Dr. Aoun: The genomic test looks at certain gene expression patterns in the indeterminate FNA sample to reclassify the nodule as benign or suspicious for cancer. When I do the biopsy, I take an extra sample to be analyzed in case the initial results are indeterminate. Thus, the Afirma test will be performed without the patient having to come back for another FNA. The overall goal is to help patients whose inconclusive nodules are actually benign to avoid surgery they would otherwise undergo.

FOR MORE INFORMATION, PLEASE CONTACT:

Dr. Paul Aoun, DO, PhD, Endocrinologist
Palm Beach Diabetes & Endocrine Specialists
(561) 659-6336
paoun@pbdes.com

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