New DNA discoveries advance MS research - NewsChannel5.com | Nashville News, Weather & Sports

New DNA discoveries advance MS research

Updated: Oct 1, 2013 02:22 PM
© iStockphoto.com / Andreas Reh © iStockphoto.com / Andreas Reh

TUESDAY, Oct. 1 (HealthDay News) -- An international team of scientists has identified 48 new genetic variants associated with multiple sclerosis (MS), a new study says.

The findings bring to 110 the number of genetic variants linked to MS and offer new insight into the biology of the progressive neurological disease.

The genes pinpointed in the new study underline the central role played by the immune system in the development of MS and show significant overlap with genes known to be involved in other autoimmune diseases, according to the study, which was published online Sept. 29 in the journal Nature Genetics.

The International Multiple Sclerosis Genetics Consortium included 193 investigators in 13 countries. They analyzed DNA from more than 29,000 people with MS and nearly 51,000 people without the disease, making it the largest MS study ever undertaken.

Although there are now 110 genetic variants known to be associated with MS, each variant individually confers only a small risk of developing the disease. Collectively, these genetic variants explain about 20 percent of the genetic component of MS, the researchers said.

The new findings are "a major step forward," according to study co-leader Jacob McCauley of the University of Miami Miller School of Medicine.

"Describing the genetic underpinnings of any complex disease is a complicated but critical step. By further refining the genetic landscape of multiple sclerosis and identifying novel genetic associations, we are closer to being able to identify the cellular and molecular processes responsible for MS and therefore the specific biological targets for future drug treatment strategies," he said in a University of Miami news release.

MS affects more than 2.5 million people worldwide, according to the news release. It causes inflammation and damage to the central nervous system that leads to problems with mobility, balance, sensation and thinking, depending upon where the damage occurs.

The risk of developing MS is higher among people who have a family history of the disease. Research in twins and adopted people has suggested that this increased risk is primarily due to genetic factors.

More information

The American Academy of Family Physicians has more about multiple sclerosis.

Copyright © 2013 HealthDay. All rights reserved.

  • Medical News HeadlinesMedical News HeadlinesMore>>

  • Nasal Spray For Alzheimer's

    Nasal Spray For Alzheimer's

    Wednesday, July 23 2014 5:15 PM EDT2014-07-23 21:15:11 GMT
    Every 70 seconds, someone in the U.S. develops Alzheimer’s disease. There is no cure, but there is new hope. From July 12-17, the greatest minds in Alzheimer’s research gathered in Copenhagen, Denmark discussing the latest breakthroughs and developments in this disease.more>>
    Every 70 seconds, someone in the U.S. develops Alzheimer’s disease. There is no cure, but there is new hope. From July 12-17, the greatest minds in Alzheimer’s research gathered in Copenhagen, Denmark discussing the latest breakthroughs and developments in this disease.more>>
  • Drug To Prevent Alzheimer's

    Drug To Prevent Alzheimer's

    Tuesday, July 22 2014 5:15 PM EDT2014-07-22 21:15:05 GMT
    Everyone-- no matter if you are a man or woman, family history or not-- with a brain is at risk for Alzheimer’s disease. Age is the biggest risk factor and America is aging. Right now, dozens of research sites across the country are testing an experimental drug to see if it might prevent memory loss associated with this terrible disease.more>>
    Everyone-- no matter if you are a man or woman, family history or not-- with a brain is at risk for Alzheimer’s disease. Age is the biggest risk factor and America is aging. Right now, dozens of research sites across the country are testing an experimental drug to see if it might prevent memory loss associated with this terrible disease.more>>
  • Could Down Syndrome Be The Key To Alzheimer's?

    Could Down Syndrome Be The Key To Alzheimer's?

    Monday, July 21 2014 5:15 PM EDT2014-07-21 21:15:13 GMT
    More than five million Americans are living with Alzheimer’s. More than 400,000 of them also have Down syndrome. What does a condition seen at birth have in common with a disease typically diagnosed in the elderly? Quite a bit.more>>
    More than five million Americans are living with Alzheimer’s. More than 400,000 of them also have Down syndrome. What does a condition seen at birth have in common with a disease typically diagnosed in the elderly? Quite a bit.more>>
  • Extreme Workouts

    Extreme Workouts

    Friday, July 18 2014 6:04 PM EDT2014-07-18 22:04:23 GMT
    Workout routines have taken a tortuous turn. Running through mud and fighting in cages are just some of the latest extreme workouts, but one wrong move and you could be in trouble.more>>
    Workout routines have taken a tortuous turn. Running through mud and fighting in cages are just some of the latest extreme workouts, but one wrong move and you could be in trouble.more>>
  • Extreme Skin

    Extreme Skin

    Thursday, July 17 2014 5:15 PM EDT2014-07-17 21:15:05 GMT
    Last year, Americans underwent more than 11-million cosmetic procedures and spent nearly $12-billion on skin rejuvenation. Everyone wants their skin to look younger, healthier and better, but some are taking it to an extreme.more>>
    Last year, Americans underwent more than 11-million cosmetic procedures and spent nearly $12-billion on skin rejuvenation. Everyone wants their skin to look younger, healthier and better, but some are taking it to an extreme.more>>
  • Extreme Diets

    Extreme Diets

    Wednesday, July 16 2014 5:15 PM EDT2014-07-16 21:15:07 GMT
    Dieting is an American pastime. About 45-million of us diet each year, and we spend about $33-billion on weight-loss products. There are more ways to diet than ever and some are pretty extreme.more>>
    Dieting is an American pastime. About 45-million of us diet each year, and we spend about $33-billion on weight-loss products. There are more ways to diet than ever and some are pretty extreme.more>>
  • Frozen Lumpectomy For Prostate

    Frozen Lumpectomy For Prostate

    Tuesday, July 15 2014 5:15 PM EDT2014-07-15 21:15:08 GMT
    More than 230,000 men will be diagnosed with prostate cancer this year according to the American Cancer Society. In most cases, surgical removal of the gland is considered the gold standard of treatment, but results of a new study suggest a new treatment might benefit some patients.more>>
    More than 230,000 men will be diagnosed with prostate cancer this year according to the American Cancer Society. In most cases, surgical removal of the gland is considered the gold standard of treatment, but results of a new study suggest a new treatment might benefit some patients.more>>
  • Bariatric Surgery For Diabetes

    Bariatric Surgery For Diabetes

    Wednesday, July 9 2014 5:15 PM EDT2014-07-09 21:15:09 GMT
    Nearly 90 percent of people with type-two diabetes are obese and as more Americans gain weight, more will likely face a diabetes diagnosis. In fact, the American Diabetes Association predicts that one in three adults will have diabetes by the year 2050. For years, we’ve heard about weight loss surgery and its effect on diabetes. Now, a new study is showing how well the popular surgery is working to stop this serious disease.more>>
    Nearly 90 percent of people with type-two diabetes are obese and as more Americans gain weight, more will likely face a diabetes diagnosis. In fact, the American Diabetes Association predicts that one in three adults will have diabetes by the year 2050. For years, we’ve heard about weight loss surgery and its effect on diabetes. Now, a new study is showing how well the popular surgery is working to stop this serious disease.more>>
  • Ankle Replacement

    Ankle Replacement

    Tuesday, July 8 2014 5:15 PM EDT2014-07-08 21:15:10 GMT
    More than 50 million Americans suffer from some form of arthritis. Between 6 percent and 13 percent of them have ankle arthritis. These patients feel pain with every single step they take, but now ankle replacements are giving patients a new lease on life.more>>
    More than 50 million Americans suffer from some form of arthritis. Between 6 percent and 13 percent of them have ankle arthritis. These patients feel pain with every single step they take, but now ankle replacements are giving patients a new lease on life.more>>
  • 3D Knee

    3D Knee

    Monday, July 7 2014 5:15 PM EDT2014-07-07 21:15:09 GMT
    In the past ten years, the number of total knee replacements in the U.S. has doubled and many of those patients are much younger than ever before. Now, new technology allows doctors to make replacement knees that are the perfect fit.more>>
    In the past ten years, the number of total knee replacements in the U.S. has doubled and many of those patients are much younger than ever before. Now, new technology allows doctors to make replacement knees that are the perfect fit.more>>
*DISCLAIMER*: The information contained in or provided through this site section is intended for general consumer understanding and education only and is not intended to be and is not a substitute for professional advice. Use of this site section and any information contained on or provided through this site section is at your own risk and any information contained on or provided through this site section is provided on an "as is" basis without any representations or warranties.
Powered by WorldNow
Powered by WorldNow
All content © Copyright 2000 - 2014 NewsChannel 5 (WTVF-TV) and WorldNow. All Rights Reserved.
For more information on this site, please read our Privacy Policy and Terms of Service.