New DNA discoveries advance MS research - NewsChannel5.com | Nashville News, Weather & Sports

New DNA discoveries advance MS research

Updated: Oct 1, 2013 02:22 PM
© iStockphoto.com / Andreas Reh © iStockphoto.com / Andreas Reh

TUESDAY, Oct. 1 (HealthDay News) -- An international team of scientists has identified 48 new genetic variants associated with multiple sclerosis (MS), a new study says.

The findings bring to 110 the number of genetic variants linked to MS and offer new insight into the biology of the progressive neurological disease.

The genes pinpointed in the new study underline the central role played by the immune system in the development of MS and show significant overlap with genes known to be involved in other autoimmune diseases, according to the study, which was published online Sept. 29 in the journal Nature Genetics.

The International Multiple Sclerosis Genetics Consortium included 193 investigators in 13 countries. They analyzed DNA from more than 29,000 people with MS and nearly 51,000 people without the disease, making it the largest MS study ever undertaken.

Although there are now 110 genetic variants known to be associated with MS, each variant individually confers only a small risk of developing the disease. Collectively, these genetic variants explain about 20 percent of the genetic component of MS, the researchers said.

The new findings are "a major step forward," according to study co-leader Jacob McCauley of the University of Miami Miller School of Medicine.

"Describing the genetic underpinnings of any complex disease is a complicated but critical step. By further refining the genetic landscape of multiple sclerosis and identifying novel genetic associations, we are closer to being able to identify the cellular and molecular processes responsible for MS and therefore the specific biological targets for future drug treatment strategies," he said in a University of Miami news release.

MS affects more than 2.5 million people worldwide, according to the news release. It causes inflammation and damage to the central nervous system that leads to problems with mobility, balance, sensation and thinking, depending upon where the damage occurs.

The risk of developing MS is higher among people who have a family history of the disease. Research in twins and adopted people has suggested that this increased risk is primarily due to genetic factors.

More information

The American Academy of Family Physicians has more about multiple sclerosis.

Copyright © 2013 HealthDay. All rights reserved.

  • Medical News HeadlinesMedical News HeadlinesMore>>

  • Growing Stem Cells In Space?

    Growing Stem Cells In Space?

    Wednesday, April 23 2014 5:15 PM EDT2014-04-23 21:15:09 GMT
    Hemorrhagic stroke is responsible for more than 30 percent of all stroke deaths. It happens when a weakened blood vessel ruptures and bleeds into the brain.more>>
    Hemorrhagic stroke is responsible for more than 30 percent of all stroke deaths. It happens when a weakened blood vessel ruptures and bleeds into the brain.more>>
  • New Laser Treatment Stops Some Epileptic Seizures

    New Laser Treatment Stops Some Epileptic Seizures

    Tuesday, April 22 2014 6:00 PM EDT2014-04-22 22:00:21 GMT
    More than two million adults in the United States have epilepsy and 150,000 more will develop the condition each year. Usually, medication can control seizures, but about 30 percent of patients do not respond. Now, patients have a new treatment option that uses lasers to stop the seizures.
    more>>
    More than two million adults in the United States have epilepsy and 150,000 more will develop the condition each year. Usually, medication can control seizures, but about 30 percent of patients do not respond. Now, patients have a new treatment option that uses lasers to stop the seizures.

    more>>
  • Heating Up Breast Cancer

    Heating Up Breast Cancer

    Monday, April 21 2014 6:15 PM EDT2014-04-21 22:15:09 GMT
    Two years ago, doctors told Lisa Ridgeway she had triple negative breast cancer, a very aggressive disease with no cure. Lisa had surgery, radiation, and chemo, but her cancer came back two more times. Now she’s trying something new.
    more>>
    Two years ago, doctors told Lisa Ridgeway she had triple negative breast cancer, a very aggressive disease with no cure. Lisa had surgery, radiation, and chemo, but her cancer came back two more times. Now she’s trying something new.

    more>>
  • Migraine Relief: Stopping Pain & Relieving Pressure

    Migraine Relief: Stopping Pain & Relieving Pressure

    Friday, April 18 2014 5:15 PM EDT2014-04-18 21:15:06 GMT
    Meredith Messerli is thankful she can study without pain. The college freshman spent two years of her life battling severe migraines.more>>
    Meredith Messerli is thankful she can study without pain. The college freshman spent two years of her life battling severe migraines.more>>
  • Hope For Lanie: Curing SMA

    Hope For Lanie: Curing SMA

    Thursday, April 17 2014 5:15 PM EDT2014-04-17 21:15:09 GMT
    SMA attacks the body's motor neurons and causes paralysis. There is no cure, but for the first time doctors are studying an experimental therapy that targets more than just symptoms.more>>
    SMA attacks the body's motor neurons and causes paralysis. There is no cure for SMA but for the first time doctors are studying an experimental therapy that targets more than just symptoms, it targets mutated SMN genes, which are responsible for SMA.more>>
  • Washing Lungs & Breathing Better

    Washing Lungs & Breathing Better

    Wednesday, April 16 2014 5:15 PM EDT2014-04-16 21:15:09 GMT
    Imagine not being able to breathe without struggling: every breath you take is work; every breath you take could be your last. That was the case for one man who became dependent on an oxygen tank to stay alive.more>>
    Imagine not being able to breathe without struggling: every breath you take is work; every breath you take could be your last. That was the case for one man who became dependent on an oxygen tank to stay alive.more>>
  • Ocular Melanoma: Saving Lives, Saving Eyes

    Ocular Melanoma: Saving Lives, Saving Eyes

    Friday, April 11 2014 5:15 PM EDT2014-04-11 21:15:07 GMT
    Ocular melanoma, also called uveal melanoma, is a rare type of melanoma that targets the eye. It can be a deadly if it isn't spotted early enough. Now, there's a way to treat patients that's saving lives and saving eyes.more>>
    Ocular melanoma, also called uveal melanoma, is a type of melanoma that targets the eye. It affects about 2,000 people a year in the United States. Although rare – it can be a deadly if it isn't spotted early enough. Now, there's a way to treat patients that's saving lives and saving eyes.more>>
  • Memory Palace: Coping With Chemo Brain

    Memory Palace: Coping With Chemo Brain

    Thursday, April 10 2014 5:15 PM EDT2014-04-10 21:15:09 GMT
    More than 13 million Americans are living with some form of cancer. Harsh treatments like chemo and radiation save lives, but they will also change lives. Now, many cancer survivors are learning how to cope with chemo brain.more>>
    More than 13 million Americans are living with some form of cancer. Harsh treatments like chemo and radiation save lives, but they will also change lives. Now, many cancer survivors are learning how to cope with chemo brain.more>>
  • Pedaling For A Cure

    Pedaling For A Cure

    Wednesday, April 9 2014 5:15 PM EDT2014-04-09 21:15:09 GMT
    Five years ago, Leslie Trudeau's world came crashing down. At just 22 years old, her son Taylor lost his battle with leukemia. That's why Trudeau is pedaling for a cure.more>>
    Five years ago, Leslie Trudeau's world came crashing down. At just 22 years old, her son Taylor lost his battle with leukemia. That's why Trudeau is pedaling for a cure.more>>
  • Bringing Hearts Back To Life: New Improved Defibrillator

    Bringing Hearts Back To Life: New Improved Defibrillator

    Tuesday, April 8 2014 5:15 PM EDT2014-04-08 21:15:13 GMT
    CPR and a portable defibrillator helped keep Eric Robinson alive after he went into cardiac arrest. And now a newly FDA approved Biotronik implantable cardiac defibrillator, or ICD, constantly monitors his heart.more>>
    A year ago, while jamming with his son's band, Eric Robinson went into cardiac arrest. CPR and a portable defibrillator helped keep Robinson alive. And now a newly FDA approved Biotronik implantable cardiac defibrillator, or ICD, constantly monitors his heart.more>>
*DISCLAIMER*: The information contained in or provided through this site section is intended for general consumer understanding and education only and is not intended to be and is not a substitute for professional advice. Use of this site section and any information contained on or provided through this site section is at your own risk and any information contained on or provided through this site section is provided on an "as is" basis without any representations or warranties.
Powered by WorldNow
Powered by WorldNow
All content © Copyright 2000 - 2014 NewsChannel 5 (WTVF-TV) and WorldNow. All Rights Reserved.
For more information on this site, please read our Privacy Policy and Terms of Service.