Scientists ID new genes linked to belly fat - NewsChannel5.com | Nashville News, Weather & Sports

Scientists ID new genes linked to belly fat

Updated: Jan 23, 2014 03:02 PM
© iStockphoto.com / Simone Vandenberg © iStockphoto.com / Simone Vandenberg

THURSDAY, Jan. 23, 2014 (HealthDay News) -- Researchers who identified five new genes linked to belly fat say their findings could help efforts to develop medicines to treat obesity or obesity-related diseases such as heart disease, diabetes and cancer.

The investigators looked at more than 57,000 people of European descent and searched for genes associated with abdominal fat, independent of overall obesity. They examined more than 50,000 variants in 2,000 genes.

The team pinpointed three new genes associated with increased waist-to-hip ratio in both women and men, and identified two other genes that appear to affect waist-to-hip ratio in women only. Waist-to-hip ratio is used to measure a person's belly fat. It's believed that genetics account for 30 percent to 60 percent of waist-to-hip ratio.

Abdominal fat is a predictor of obesity-related disease, according to the U.S. Centers for Disease Control and Prevention.

The new study found that of the two genes that only seem to affect women, one called SHC1 appears to interact with 17 other proteins known to play a role in obesity. SHC1 has been found to be highly active in fat tissue.

"This is the first time SHC1 has been associated with abdominal fat," study author Kira Taylor, an assistant professor at the University of Louisville School of Public Health and Information Sciences, said in a university news release.

"We believe this discovery holds great opportunity for medicinal chemistry and eventually, personalized medicine," Taylor said. "If scientists can find a way to fine-tune the [activity] of this gene, we could potentially reduce the risk of excessive fat in the mid-section and its consequences, such as cardiovascular disease."

The study was recently published online in the journal Human Molecular Genetics.

Previous research has found that mice without the SHC1 protein are leaner than those with the protein, the news release noted.

More information

The U.S. National Heart, Lung, and Blood Institute has more about overweight and obesity.

Copyright © 2014 HealthDay. All rights reserved.

  • Medical News HeadlinesMedical News HeadlinesMore>>

  • Hope For Lanie: Curing SMA

    Hope For Lanie: Curing SMA

    Thursday, April 17 2014 5:15 PM EDT2014-04-17 21:15:09 GMT
    SMA attacks the body's motor neurons and causes paralysis. There is no cure, but for the first time doctors are studying an experimental therapy that targets more than just symptoms.more>>
    SMA attacks the body's motor neurons and causes paralysis. There is no cure for SMA but for the first time doctors are studying an experimental therapy that targets more than just symptoms, it targets mutated SMN genes, which are responsible for SMA.more>>
  • Washing Lungs & Breathing Better

    Washing Lungs & Breathing Better

    Wednesday, April 16 2014 5:15 PM EDT2014-04-16 21:15:09 GMT
    Imagine not being able to breathe without struggling: every breath you take is work; every breath you take could be your last. That was the case for one man who became dependent on an oxygen tank to stay alive.more>>
    Imagine not being able to breathe without struggling: every breath you take is work; every breath you take could be your last. That was the case for one man who became dependent on an oxygen tank to stay alive.more>>
  • Ocular Melanoma: Saving Lives, Saving Eyes

    Ocular Melanoma: Saving Lives, Saving Eyes

    Friday, April 11 2014 5:15 PM EDT2014-04-11 21:15:07 GMT
    Ocular melanoma, also called uveal melanoma, is a rare type of melanoma that targets the eye. It can be a deadly if it isn't spotted early enough. Now, there's a way to treat patients that's saving lives and saving eyes.more>>
    Ocular melanoma, also called uveal melanoma, is a type of melanoma that targets the eye. It affects about 2,000 people a year in the United States. Although rare – it can be a deadly if it isn't spotted early enough. Now, there's a way to treat patients that's saving lives and saving eyes.more>>
  • Memory Palace: Coping With Chemo Brain

    Memory Palace: Coping With Chemo Brain

    Thursday, April 10 2014 5:15 PM EDT2014-04-10 21:15:09 GMT
    More than 13 million Americans are living with some form of cancer. Harsh treatments like chemo and radiation save lives, but they will also change lives. Now, many cancer survivors are learning how to cope with chemo brain.more>>
    More than 13 million Americans are living with some form of cancer. Harsh treatments like chemo and radiation save lives, but they will also change lives. Now, many cancer survivors are learning how to cope with chemo brain.more>>
  • Pedaling For A Cure

    Pedaling For A Cure

    Wednesday, April 9 2014 5:15 PM EDT2014-04-09 21:15:09 GMT
    Five years ago, Leslie Trudeau's world came crashing down. At just 22 years old, her son Taylor lost his battle with leukemia. That's why Trudeau is pedaling for a cure.more>>
    Five years ago, Leslie Trudeau's world came crashing down. At just 22 years old, her son Taylor lost his battle with leukemia. That's why Trudeau is pedaling for a cure.more>>
  • Bringing Hearts Back To Life: New Improved Defibrillator

    Bringing Hearts Back To Life: New Improved Defibrillator

    Tuesday, April 8 2014 5:15 PM EDT2014-04-08 21:15:13 GMT
    CPR and a portable defibrillator helped keep Eric Robinson alive after he went into cardiac arrest. And now a newly FDA approved Biotronik implantable cardiac defibrillator, or ICD, constantly monitors his heart.more>>
    A year ago, while jamming with his son's band, Eric Robinson went into cardiac arrest. CPR and a portable defibrillator helped keep Robinson alive. And now a newly FDA approved Biotronik implantable cardiac defibrillator, or ICD, constantly monitors his heart.more>>
  • Helping High Risk Hearts

    Helping High Risk Hearts

    Monday, April 7 2014 5:15 PM EDT2014-04-07 21:15:09 GMT
    Ironing is not exactly Barbara Roy's favorite activity, but it's something she's glad she can do again. Her doctor diagnosed her with severe aortic stenosis.more>>
    Ironing is not exactly Barbara Roy's favorite activity, but it's something she's glad she can do again. Her doctor diagnosed her with severe aortic stenosis.more>>
  • Hernias In Newborns: Lincoln's Story

    Hernias In Newborns: Lincoln's Story

    Friday, April 4 2014 5:15 PM EDT2014-04-04 21:15:07 GMT
    Congenital diaphragmatic hernias occur in about one in every 2,000 births. They can be deadly, but now doctors are using a more aggressive treatment approach.more>>
    Congenital diaphragmatic hernias occur in about one in every 2,000 births. They can be deadly, but now doctors are using a more aggressive treatment approach.more>>
  • Predicting Bad Hearts

    Predicting Bad Hearts

    Thursday, April 3 2014 5:15 PM EDT2014-04-03 21:15:09 GMT
    Every year, more than 700,000 Americans have a heart attack. Now, researchers at Baylor Research Institute at Dallas have uncovered a biomarker that may help them spot the disease sooner.more>>
    Every year, more than 700,000 Americans have a heart attack. And 600,000 die of heart disease. Now, researchers at Baylor Research Institute at Dallas have uncovered a biomarker that may help them spot the disease sooner; and they did it by pure accident.more>>
  • Giving Shannon A Voice Of Her Own

    Giving Shannon A Voice Of Her Own

    Wednesday, April 2 2014 5:15 PM EDT2014-04-02 21:15:05 GMT
    More than half a million children under age 15 has a severe communication disorder impairing their ability to speak or communicate with others. Now, advances in technology are giving them a voice—some for the first time.more>>
    More than half a million children under age 15 has a severe communication disorder impairing their ability to speak or communicate with others. Now, advances in technology are giving them a voice—some for the first time.more>>
*DISCLAIMER*: The information contained in or provided through this site section is intended for general consumer understanding and education only and is not intended to be and is not a substitute for professional advice. Use of this site section and any information contained on or provided through this site section is at your own risk and any information contained on or provided through this site section is provided on an "as is" basis without any representations or warranties.
Powered by WorldNow
Powered by WorldNow
All content © Copyright 2000 - 2014 NewsChannel 5 (WTVF-TV) and WorldNow. All Rights Reserved.
For more information on this site, please read our Privacy Policy and Terms of Service.