The 26th annual St. Jude Rock 'n' Roll Running Series is taking place on Saturday and Sunday, April 25 and 26 across Music City and we have everything you need to know ahead of the race.

There are five different races, including the full marathon, half marathon, 10k, 5k, and 1-mile.

The marathon kicks off at 7:20 a.m. on Saturday and will spread throughout the city.

Because of this, there are dozens of road closures in place, some of which begin on Friday.

Most road closures and detours on Saturday will be in effect between the hours of 5:00 a.m. and 2:30 p.m.

Streets will reopen on a rolling basis as soon as the last participant has passed. There are a number of neighborhood and area specific tips that can be found below.