Interstate 65 southbound is closed in Sumner County just before Exit 98 due to an overturned semi-truck, officials said.
The crash involves a tractor-trailer hauling horses. Authorities confirmed all of the animals are contained.
Traffic is being diverted at mile marker 104 as crews work the scene.
The estimated total clearance time is 5 p.m. Officials have not released information about injuries or what caused the crash.
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