Thomas Bryant scored 17 of his 19 points in the second half, Yogi Ferrell had 18 and fifth-seeded Indiana beat Kentucky 73-67 Saturday to earn a spot in the Sweet 16.
The Hoosiers (27-7) will return to the regional semifinals for the first time since 2012, despite losing starting guard Robert Johnson to an apparent left ankle injury late in the first half.
Indiana took control with a 17-4 run to go up 10 with four minutes left. Tyler Ulis and Alex Poythress pulled Kentucky within 69-67 on free throws, but Bryant hit two from the line with 10 seconds to go to seal the win.
Ulis scored 27 points for Kentucky (27-9), which suffered its earliest NCAA Tournament exit since 2008.